TRPA1

Description		transient receptor potential cation channel subfamily A member 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Axon Stereocilium Bundle
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Channel Activity Intracellularly Gated Calcium Channel Activity Gated Channel Activity Identical Protein Binding Temperature-gated Cation Channel Activity Osmolarity-sensing Monoatomic Cation Channel Activity
	Biological Process	System Process Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To Cold Response To Xenobiotic Stimulus Urinary Bladder Smooth Muscle Contraction Sensory Perception Of Pain Calcium-mediated Signaling Cellular Response To Stress Monoatomic Ion Transmembrane Transport Cellular Response To Heat Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Hydrogen Peroxide Response To Pain Thermoception Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Protein Homotetramerization Transmembrane Transport Cellular Response To Hydrogen Peroxide Cellular Response To Cold Calcium Ion Transmembrane Transport Cellular Response To Food Cellular Response To Carbon Dioxide Cellular Response To Caffeine Cellular Response To Toxic Substance Calcium Ion Transmembrane Import Into Cytosol Regulation Of Neuronal Action Potential Cellular Response To Oxygen-containing Compound Regulation Of Blood Circulation Positive Regulation Of Monoatomic Anion Transport
Pathways		TRP channels
Drugs		Levomenthol Camphor Cannabidiol Butamben (S)-camphor Tetrahydrocannabivarin Medical Cannabis Nabiximols Cannabidivarin
Diseases
GWAS		Adult asthma ( 27611488) Coronary artery disease ( 26708285) Gout ( 22179738) Lung cancer in ever smokers ( 28604730) Metabolite levels ( 23823483) Myocardial infarction ( 26708285) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: LYN
Interacting Genes		1 interacting genes: LYN
Entrez ID		8989
HPRD ID		09208
Ensembl ID		ENSG00000104321
Uniprot IDs		O75762
PDB IDs		3J9P 6HC8 6PQO 6PQP 6PQQ 6V9V 6V9W 6V9X 6V9Y 6WJ5 6X2J 7JUP 7OR0 7OR1
Enriched GO Terms of Interacting Partners?		Regulation Of Oligodendrocyte Progenitor Proliferation Platelet Degranulation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Mitochondrial Crista Interleukin-5-mediated Signaling Pathway Regulation Of Mast Cell Proliferation Positive Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Signaling Receptor Activator Activity Phosphorylation-dependent Protein Binding Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Histamine Transport Immune Response-inhibiting Signal Transduction Response To Sterol Depletion Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Neuroinflammatory Response Negative Regulation Of B Cell Proliferation Regulation Of Mast Cell Activation Negative Regulation Of MAP Kinase Activity Growth Hormone Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Glial Cell Proliferation Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Cellular Response To Lectin Tolerance Induction Fc-epsilon Receptor Signaling Pathway Oligodendrocyte Development Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Platelet Aggregation Granulocyte Differentiation
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