MTMR2

Description		myotubularin related protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Vacuolar Membrane Cytosol Synaptic Vesicle Endosome Membrane Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Cell Projection Dendritic Spine Perinuclear Region Of Cytoplasm Extracellular Exosome Synaptic Membrane
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Identical Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity
	Biological Process	Negative Regulation Of Receptor Internalization Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Myelination Negative Regulation Of Endocytosis Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Neuron Development Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Appendicular lean mass ( 33097823) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883) Waist circumference adjusted for body mass index ( 28552196)
Novel Interacting Genes		7 novel interacting genes: ERBB3 ERBB4 NEFL ROR2 RSPH1 SBF1 SNTA1
Interacting Genes		7 interacting genes: ERBB3 ERBB4 NEFL ROR2 RSPH1 SBF1 SNTA1
Entrez ID		8898
HPRD ID		04650
Ensembl ID		ENSG00000087053
Uniprot IDs		Q13614
PDB IDs		1LW3 1M7R 1ZSQ 1ZVR 5GNH
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity Neuromuscular Junction Regulation Of Motor Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activity ERBB2 Signaling Pathway Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Lateral Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Central Nervous System Morphogenesis Response To Acrylamide Intermediate Filament Polymerization Or Depolymerization Presynaptic Intermediate Filament Cytoskeleton Spermatid Development Neuron Apoptotic Process Epidermal Growth Factor Receptor Activity Regeneration Neurofilament Bundle Assembly Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Radial Spoke Head 1 Radial Spoke Head 3 Kinase Activity Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation Postsynaptic Intermediate Filament Cytoskeleton Syntrophin Complex Enzyme-linked Receptor Protein Signaling Pathway ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Neuron Apoptotic Process ERBB2-ERBB4 Signaling Pathway Regulation Of Axon Diameter Radial Spoke Head ERBB4-ERBB4 Signaling Pathway Response To Sodium Arsenite Germ Cell Development Positive Regulation Of Epithelial Cell Proliferation Schwann Cell Differentiation Response To Wounding
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