DDX18

Description		DEAD-box helicase 18
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GO Annotations	Cellular Component	Nucleus Chromosome Nucleolus Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cellular Response To Estradiol Stimulus
Pathways
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Neuritic plaque ( 31497858) Opioid overdose severity score ( 31362332) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Urate levels (BMI interaction) ( 25811787)
Novel Interacting Genes		5 novel interacting genes: APP BTG3 CRMP1 MTA1 PATJ
Interacting Genes		5 interacting genes: APP BTG3 CRMP1 MTA1 PATJ
Entrez ID		8886
HPRD ID		05894
Ensembl ID		ENSG00000088205
Uniprot IDs		Q8N254 Q9NVP1
PDB IDs		3LY5 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Synapse Assembly Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Growth Cone Regulation Of Postsynapse Organization Lipoprotein Particle Perikaryon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Protein Autoubiquitination Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Locomotory Behavior Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Presynapse Regulation Of Spontaneous Synaptic Transmission Postsynapse NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Dihydropyrimidinase Activity Regulation Of Protein Autoubiquitination Axon Choice Point Recognition Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Regulation Of Cell Junction Assembly Heparan Sulfate Binding Signaling Receptor Activator Activity Pyrimidine Nucleobase Catabolic Process Epigenetic Regulation Of Gene Expression Peptidase Activator Activity Cellular Response To Manganese Ion
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