ALDH1A2

Description		aldehyde dehydrogenase 1 family member A2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Retinal Dehydrogenase (NAD+) Activity 3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Retinal Binding
	Biological Process	Blood Vessel Development Kidney Development Liver Development Retinoic Acid Biosynthetic Process Heart Morphogenesis Aldehyde Metabolic Process Lipid Metabolic Process Vitamin A Metabolic Process Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Determination Of Bilateral Symmetry Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Neural Crest Cell Development Morphogenesis Of Embryonic Epithelium Neural Tube Development Pituitary Gland Development Neuron Differentiation Lung Development Embryonic Limb Morphogenesis Forebrain Development Hindbrain Development Pancreas Development Embryonic Camera-type Eye Development Response To Estradiol Response To Retinoic Acid Response To Vitamin A Response To Cytokine Embryonic Forelimb Morphogenesis Ureter Maturation Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Positive Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Cardiac Muscle Tissue Development Protein Homotetramerization Face Development Cellular Response To Retinoic Acid Regulation Of Vascular Endothelial Cell Proliferation
Pathways		RA biosynthesis pathway
Drugs		NADH Vitamin A Tretinoin
Diseases
GWAS		Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain morphology (MOSTest) ( 32665545) Cholesterol ( 31902109) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) HDL cholesterol ( 30275531 28270201) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hypertension ( 19609347) Ischemic stroke ( 26089329) LDL cholesterol ( 30275531) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low HDL-cholesterol levels ( 31910446) Lymphocyte count ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Osteoarthritis (hand, severe) ( 24728293) Red blood cell count ( 32888494) Serum metabolite levels ( 33031748) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Total cholesterol levels ( 30275531) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Triglyceride levels ( 32154731) Uncontrolled blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388)
Novel Interacting Genes		3 novel interacting genes: HTRA2 OGT UBE3A
Interacting Genes		3 interacting genes: HTRA2 OGT UBE3A
Entrez ID		8854
HPRD ID		04733
Ensembl ID		ENSG00000128918
Uniprot IDs		O94788
PDB IDs		4X2Q 6ALJ 6B5G 6B5H 6B5I
Enriched GO Terms of Interacting Partners?		Positive Regulation Of TOR Signaling Sperm Entry Positive Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Regulation Of Protein Localization Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Pentacyclic Triterpenoid Metabolic Process Regulation Of TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Mitochondrial Membrane Protein Processing Negative Regulation Of Type 2 Mitophagy Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Rhythmic Process Regulation Of Golgi Lumen Acidification Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Cellular Response To Nutrient Levels Negative Regulation Of Signaling Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular PH Reduction Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Herbicide Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Protein Maturation Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Proteolysis Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Transcription By Glucose Prostate Gland Growth Mitochondrial Protein Catabolic Process Serine-type Endopeptidase Complex Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand NSL Complex CD40 Receptor Complex Progesterone Receptor Signaling Pathway Ubiquitin Ligase Inhibitor Activity
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