SYNGAP1

Description		synaptic Ras GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Dendritic Shaft Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Ras Protein Signal Transduction Pattern Specification Process Axonogenesis Visual Learning Dendrite Development Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Modulation Of Chemical Synaptic Transmission Neuron Apoptotic Process Maintenance Of Postsynaptic Specialization Structure Regulation Of Intracellular Signal Transduction
Pathways		Regulation of RAS by GAPs
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Novel Interacting Genes		32 novel interacting genes: CAMK2A CRK DLG3 DLG4 DLGAP4 DSCAM EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR LCOR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX
Interacting Genes		32 interacting genes: CAMK2A CRK DLG3 DLG4 DLGAP4 DSCAM EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR LCOR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX
Entrez ID		8831
HPRD ID		16018
Ensembl ID		ENSG00000197283
Uniprot IDs		A0A1U9X8L0 B7ZCA0 Q96PV0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Glutamate Binding Postsynaptic Density Positive Regulation Of Synaptic Transmission, Glutamatergic NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Postsynaptic Density Membrane Regulation Of Synaptic Plasticity Dendritic Spine Development Neuron Projection Glutamate Receptor Signaling Pathway Regulation Of Nervous System Process Protein Autophosphorylation Synapse Developmental Process Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Neuromuscular Junction Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Binding Chemical Synaptic Transmission Ionotropic Glutamate Receptor Binding Modulation Of Chemical Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Trans-synaptic Signaling AMPA Glutamate Receptor Clustering Protein Phosphorylation Kinase Binding Synaptic Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Postsynaptic Membrane Phosphorylation Synaptic Transmission, Glutamatergic Neuron Spine Protein Modification Process Receptor Clustering Neuron Projection Morphogenesis Long-term Synaptic Potentiation Signaling Regulation Of Membrane Potential Social Behavior Glycine Binding
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