FGF18

Description		fibroblast growth factor 18
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleolus Cytoplasm
	Molecular Function	Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process	Ossification Angiogenesis Regulation Of Endothelial Cell Proliferation Intramembranous Ossification Endochondral Ossification Chondrocyte Differentiation Chondrocyte Development Signal Transduction Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Neurogenesis Lung Development Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR3 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Cocaine dependence (time to event) ( 34124712) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 25282103 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30804560) Multisite chronic pain ( 33830993) Peak expiratory flow ( 30804560) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		6 novel interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 LYAR PTX3
Interacting Genes		6 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 LYAR PTX3
Entrez ID		8817
HPRD ID		04766
Ensembl ID		ENSG00000156427
Uniprot IDs		O76093
PDB IDs		4CJM
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Receptor Complex Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Catalytic Activity Biomineral Tissue Development Lung-associated Mesenchyme Development Endochondral Bone Growth Positive Regulation Of Hydrolase Activity Branching Involved In Salivary Gland Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Protein Autophosphorylation Protein Kinase Activity Bone Growth Heparin Binding Regulation Of Catalytic Activity Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Identical Protein Binding Positive Regulation Of Metabolic Process Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Mesonephric Tubule Development Positive Regulation Of Cell Population Proliferation Mesonephric Epithelium Development Positive Regulation Of Organ Growth
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