SLC4A4

Description		solute carrier family 4 member 4
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extracellular Exosome
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Sodium:bicarbonate Symporter Activity Symporter Activity Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Positive Regulation Of Glycolytic Process Regulation Of Intracellular PH Transmembrane Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Bicarbonate transporters Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Proximal renal tubular acidosis (RTA type 2)
GWAS		Age-related nuclear cataracts ( 24951543) Diastolic blood pressure ( 30578418) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 28869591 30598549) Mosquito bite size ( 28199695) QT interval ( 24952745 29874175) Refractive error ( 32231278)
Novel Interacting Genes		5 novel interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2
Interacting Genes		5 interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2
Entrez ID		8671
HPRD ID		04516
Ensembl ID		ENSG00000080493
Uniprot IDs		A5JJ20 Q9Y6R1
PDB IDs		6CAA
Enriched GO Terms of Interacting Partners?		Carbonate Dehydratase Activity Bicarbonate Transport Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Chemical Homeostasis Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Cellular Response To Fluid Shear Stress Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Cholesterol Metabolic Process Intracellular PH Reduction Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Homeostatic Process Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Steroid Biosynthetic Process Regulation Of Intracellular PH Regulation Of Cellular PH Intracellular Chemical Homeostasis Regulation Of PH Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Cellular Homeostasis Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity C-8 Sterol Isomerase Activity Positive Regulation Of Lipid Metabolic Process Lyase Activity Positive Regulation Of Small Molecule Metabolic Process SREBP-SCAP-Insig Complex Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Sodium:bicarbonate Symporter Activity Regulation Of Lipid Biosynthetic Process Regulation Of Macroautophagy Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Chloride Transport CAMP-dependent Protein Kinase Activity Basolateral Plasma Membrane Channel Activator Activity Positive Regulation Of Cholesterol Storage Auditory Receptor Cell Development Phagosome Acidification Cellular Response To Nutrient Levels CAMP/PKA Signal Transduction
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