KMO

Description		kynurenine 3-monooxygenase
Image
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	Monooxygenase Activity Kynurenine 3-monooxygenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	L-tryptophan Catabolic Process NAD+ Biosynthetic Process Response To Salt Stress Positive Regulation Of Glutamate Secretion Pyridine Nucleotide Biosynthetic Process NAD+ Metabolic Process Quinolinate Biosynthetic Process Response To Lipopolysaccharide Kynurenic Acid Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Anthranilate Metabolic Process Kynurenine Metabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 L-kynurenine Metabolic Process Positive Regulation Of Glutamate Secretion, Neurotransmission
Pathways		Tryptophan catabolism
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)
Novel Interacting Genes		1 novel interacting genes: FBXO7
Interacting Genes		1 interacting genes: FBXO7
Entrez ID		8564
HPRD ID		04642
Ensembl ID		ENSG00000117009
Uniprot IDs		A8K693 O15229
PDB IDs		5X68
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitophagy Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Autophagy Of Mitochondrion Autophagy Of Mitochondrion SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex Positive Regulation Of Macroautophagy Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Ubiquitin Binding Negative Regulation Of Hemopoiesis Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Autophagy Negative Regulation Of Neuron Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Activation Protein Targeting Regulation Of Lymphocyte Differentiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Macroautophagy Negative Regulation Of Leukocyte Activation Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Lymphocyte Differentiation Ubiquitin-protein Transferase Activity
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