ALG2

Description		ALG2 alpha-1,3/1,6-mannosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG2 causes CDG-1i
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Asthma ( 31959851 34103634) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031)
Novel Interacting Genes		4 novel interacting genes: ANXA11 PEF1 PTPN23 SRI
Interacting Genes		4 interacting genes: ANXA11 PEF1 PTPN23 SRI
Entrez ID		85365
HPRD ID		09716
Ensembl ID		ENSG00000119523
Uniprot IDs		A0A0A0MTE0 Q9H553
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding Extracellular Exosome Calcium Ion Binding Positive Regulation Of Homophilic Cell Adhesion Response To Calcium Ion Positive Regulation Of Adherens Junction Organization Vesicle-mediated Transport Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of Wnt Protein Secretion Regulation Of Adherens Junction Organization Regulation Of Homophilic Cell Adhesion Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Secretion Regulation Of Protein Monoubiquitination Negative Regulation Of Striated Muscle Contraction Chromaffin Granule Membrane Neural Crest Formation Response To Metal Ion Positive Regulation Of Early Endosome To Late Endosome Transport Protein Heterodimerization Activity Azurophil Granule Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Phosphatidylethanolamine Binding S100 Protein Binding Specific Granule Regulation Of Cell Communication By Electrical Coupling Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Regulation Of Protein Transport Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Epithelial Cell Migration COPII Vesicle Coat Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Regulation Of Establishment Of Protein Localization Negative Regulation Of Blood Circulation Regulation Of Cellular Localization Early Endosome To Late Endosome Transport COPII Vesicle Coating MHC Class II Protein Complex Binding Regulation Of Secretion By Cell Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Neural Crest Cell Development Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Cardiac Muscle Cell Contraction Regulation Of Secretion Vesicle Membrane Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Tagcloud ?