CGNL1

Description		cingulin like 1
Image		No pdb structure
GO Annotations	Cellular Component	Bicellular Tight Junction Actin Cytoskeleton Myosin Complex Protein-containing Complex Apical Junction Complex Anchoring Junction
	Molecular Function	Protein Binding
	Biological Process	Actin Filament Organization Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Protein Localization To Cell-cell Junction
Pathways
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Atrial fibrillation ( 28416818) Bipolar disorder (age of onset and psychotic symptoms) ( 21305692) Estimated glomerular filtration rate ( 31015462 31152163) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Macular thickness ( 30535121) Red blood cell count ( 32888494) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)
Novel Interacting Genes		5 novel interacting genes: APC USP7 YWHAE YWHAG YWHAZ
Interacting Genes		5 interacting genes: APC USP7 YWHAE YWHAG YWHAZ
Entrez ID		84952
HPRD ID		09708
Ensembl ID		ENSG00000128849
Uniprot IDs		Q0VF96
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization Protein Sequestering Activity Negative Regulation Of TORC1 Signaling TORC1 Signaling Phosphoserine Residue Binding TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Stress Regulation Of TOR Signaling Intracellular Signal Transduction Protein Targeting Protein Domain Specific Binding Cellular Response To Nutrient Levels Ubiquitin Protein Ligase Binding Cadherin Binding Cellular Response To Glucose Starvation Regulation Of Protein Stability Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Focal Adhesion Regulation Of Signal Transduction Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Response To Stress Proteasomal Protein Catabolic Process Response To Nutrient Levels Negative Regulation Of Immune System Process Protein Phosphatase Binding Regulation Of Cell Communication Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Melanosome Protein Modification Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Phosphorylation Proteolysis Involved In Protein Catabolic Process Regulation Of Heart Rate By Hormone Synaptic Target Recognition Protein Modification By Small Protein Conjugation Transmembrane Transporter Binding Negative Regulation Of Catalytic Activity
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