ORAI1

Description		ORAI calcium release-activated calcium modulator 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Calcium Channel Complex Plasma Membrane Raft Membrane Raft
	Molecular Function	Calcium Channel Activity Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding
	Biological Process	Store-operated Calcium Entry Adaptive Immune Response Immune System Process Monoatomic Ion Transport Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Calcineurin-NFAT Signaling Cascade Monoatomic Ion Transmembrane Transport Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Mammary Gland Epithelium Development Calcium Ion Import Calcium Ion Transmembrane Transport Ligand-gated Ion Channel Signaling Pathway
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Experiencing mood swings ( 29500382) Major depressive disorder ( 27777418)
Novel Interacting Genes		2 novel interacting genes: TRPC3 TRPC6
Interacting Genes		2 interacting genes: TRPC3 TRPC6
Entrez ID		84876
HPRD ID		08599
Ensembl ID		ENSG00000276045
Uniprot IDs		Q96D31
PDB IDs		2MAK 4EHQ
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cation Channel Complex Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Single Fertilization Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Fertilization Positive Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Channel Activity Intracellular Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transport Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Calcium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Metal Ion Transport Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Regulation Of Monoatomic Ion Transport Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Slit Diaphragm Negative Regulation Of Dendrite Morphogenesis Metal Ion Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Calcium-activated Cation Channel Activity Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Positive Regulation Of Calcium Ion Transport Into Cytosol Inorganic Ion Transmembrane Transport Actinin Binding Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Chemical Homeostasis Monoatomic Ion Transport Response To ATP Monoatomic Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Clathrin Binding Positive Regulation Of Cardiac Muscle Hypertrophy Transmembrane Transport
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