KLHL22

Description		kelch like family member 22
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Cytoskeleton Cul3-RING Ubiquitin Ligase Complex Intercellular Bridge Mitotic Spindle
	Molecular Function	Protein Binding 14-3-3 Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Mitotic Sister Chromatid Segregation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Amino Acid Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Cell Division Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lung function (FEV1/FVC) ( 30061609) Retinopathy in non-diabetics ( 23393555)
Novel Interacting Genes		6 novel interacting genes: ADRA1A CUL3 DEPDC5 GLUD1 PLK1 RBX1
Interacting Genes		6 interacting genes: ADRA1A CUL3 DEPDC5 GLUD1 PLK1 RBX1
Entrez ID		84861
HPRD ID		07858
Ensembl ID		ENSG00000099910
Uniprot IDs		Q53GT1
PDB IDs		8K8T 8K9I 8KHP 8W4J
Enriched GO Terms of Interacting Partners?		Cellular Response To Amino Acid Starvation Cul3-RING Ubiquitin Ligase Complex Negative Regulation Of TORC1 Signaling Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Mitotic Cell Cycle Phase Transition Regulation Of TOR Signaling Cell Cycle Phase Transition RNA Polymerase II Transcription Initiation Surveillance Renal Sodium Ion Absorption Cellular Response To Starvation Renal Sodium Ion Transport Regulation Of Protein Ubiquitination Response To Starvation Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Nuclear RNA Surveillance Cellular Response To Nutrient Levels RNA Surveillance Renal Absorption Negative Regulation Of Type I Interferon Production Transcription Elongation By RNA Polymerase II Type I Interferon-mediated Signaling Pathway DNA-templated Transcription Elongation Protein Monoubiquitination Protein Destabilization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Autophagy Positive Regulation Of Protein Modification Process TORC1 Signaling Interferon-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Chromosome Separation Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cellular Response To Amino Acid Stimulus TOR Signaling Regulation Of Cytokinesis
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