SPIRE2

Description		spire type actin nucleation factor 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cleavage Furrow
	Molecular Function	Actin Binding Protein Binding Microtubule Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Actin Cytoskeleton Organization Cleavage Furrow Formation Polar Body Extrusion After Meiotic Divisions Actin Nucleation Intracellular Transport Golgi Vesicle Transport Establishment Of Meiotic Spindle Localization Actin Filament Network Formation Formin-nucleated Actin Cable Assembly Positive Regulation Of Double-strand Break Repair
Pathways
Drugs		Latrunculin B
Diseases
GWAS		Basal cell carcinoma ( 33549134) Brain morphology (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Left–right brain asymmetry ( 33723403) Low tan response ( 29739929) Mean reticulocyte volume ( 32888494) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Red vs. brown/black hair color ( 30531825) White matter integrity (fractional anisotropy) ( 32358547)
Novel Interacting Genes		2 novel interacting genes: HGS IRF8
Interacting Genes		2 interacting genes: HGS IRF8
Entrez ID		84501
HPRD ID		18099
Ensembl ID		ENSG00000204991
Uniprot IDs		Q8WWL2
PDB IDs		5JCY
Enriched GO Terms of Interacting Partners?		Autophagy Plasmacytoid Dendritic Cell Activation Plasmacytoid Dendritic Cell Differentiation Follicular B Cell Differentiation ESCRT-0 Complex Phagocytic Vesicle Lumen Endocytosis Germinal Center B Cell Differentiation Import Into Cell Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Protozoan Defense Response To Protozoan Mature B Cell Differentiation Mature B Cell Differentiation Involved In Immune Response Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Membrane Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Organization Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Targeting To Lysosome Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Exosomal Secretion Ubiquitin-like Protein Ligase Binding Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Exosomal Secretion Vesicle-mediated Transport Dendritic Cell Differentiation Late Endosome To Vacuole Transport Positive Regulation Of Interleukin-12 Production Positive Regulation Of Gene Expression Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Membrane Invagination Multivesicular Body Sorting Pathway Protein Targeting To Vacuole Protein Localization To Lysosome B Cell Activation Involved In Immune Response Regulation Of Interleukin-12 Production Regulation Of MAP Kinase Activity Establishment Of Protein Localization To Vacuole Cellular Response To Type II Interferon Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Type II Interferon Production Endocytic Recycling Positive Regulation Of Exocytosis Endosome Organization
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