CARD11

Description		caspase recruitment domain family member 11
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Membrane CBM Complex Membrane Raft Extracellular Exosome
	Molecular Function	GMP Kinase Activity Protein Binding CARD Domain Binding
	Biological Process	Immune System Process Signal Transduction Canonical NF-kappaB Signal Transduction B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production CD4-positive, Alpha-beta T Cell Proliferation TORC1 Signaling B Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process Lymphocyte Activation GDP Metabolic Process Homeostasis Of Number Of Cells Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
Drugs
Diseases
GWAS		Asthma ( 34103634) Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 24076602 31604244) Response to fenofibrate (total cholesterol levels) ( 27002377) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)
Novel Interacting Genes		15 novel interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70
Interacting Genes		15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70
Entrez ID		84433
HPRD ID		06234
Ensembl ID		ENSG00000198286
Uniprot IDs		Q9BXL7
PDB IDs		4JUP 4LWD
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Immune System Process Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Protein Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Serine Kinase Activity Protein Phosphorylation Immune Response-activating Signaling Pathway Regulation Of Immune Response Kinase Activity Phosphorylation Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Signal Transduction Activation Of Immune Response Positive Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Linear Polyubiquitin Binding Non-canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Immunological Synapse MAP Kinase Kinase Kinase Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Cytosol Canonical NF-kappaB Signal Transduction Regulation Of Immune System Process JNK Cascade Positive Regulation Of CGAS/STING Signaling Pathway Lymphocyte Homeostasis Protein Modification Process Transferase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Leukocyte Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Anoikis Protein Serine/threonine Phosphatase Activity Kinase Activator Activity Positive Regulation Of T Cell Activation Phosphate-containing Compound Metabolic Process
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