SOAT2

Description		sterol O-acyltransferase 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Brush Border Membrane
	Molecular Function	Fatty-acyl-CoA Binding Sterol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Cholesterol Binding Transferase Activity Acyltransferase Activity Cholesterol O-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Macrophage Derived Foam Cell Differentiation Cholesterol Storage Intestinal Cholesterol Absorption Cholesterol Efflux Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis
Pathways		LDL clearance
Drugs		Hesperetin
Diseases
GWAS		Appendicular lean mass ( 33097823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Novel Interacting Genes		1 novel interacting genes: TMBIM6
Interacting Genes		1 interacting genes: TMBIM6
Entrez ID		8435
HPRD ID		03202
Ensembl ID		ENSG00000167780
Uniprot IDs		O75908
PDB IDs		7N6Q 7N6R
Enriched GO Terms of Interacting Partners?		Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Endoribonuclease Inhibitor Activity Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To Unfolded Protein Regulation Of Cellular Response To Hypoxia Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cytosolic Calcium Ion Concentration IRE1-mediated Unfolded Protein Response Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Immunoglobulin Production Cellular Response To Topologically Incorrect Protein Negative Regulation Of RNA Splicing Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Calcium Ion Transport Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Immunoglobulin Production Response To Unfolded Protein Calcium Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Monoatomic Ion Transport Response To Amino Acid Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Splicing Intracellular Calcium Ion Homeostasis Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Autophagy
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