PHF6

Description		PHD finger protein 6
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding Tubulin Binding Enzyme Binding Histone Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Metal Ion Binding Phosphoprotein Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching
Pathways
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Novel Interacting Genes		3 novel interacting genes: CEBPA OGT SRPK2
Interacting Genes		3 interacting genes: CEBPA OGT SRPK2
Entrez ID		84295
HPRD ID		02330
Ensembl ID		ENSG00000156531
Uniprot IDs		Q8IWS0
PDB IDs		4NN2 4R7A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Carbohydrate Homeostasis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin DNA Binding Positive Regulation Of Gene Expression Regulation Of Ubiquitin-dependent Protein Catabolic Process Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Nutrient Response To Vitamin B2 C/EBP Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Defense Response CHOP-C/EBP Complex Protein O-acetylglucosaminyltransferase Activity White Fat Cell Proliferation Nuclear Speck Organization Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Response To Phenylpropanoid Intracellular Signal Transduction Carbon Catabolite Regulation Of Transcription Regulation Of Protein Catabolic Process Fat Cell Proliferation Regulation Of Proteolysis R-loop Processing Regulation Of Transcription By Glucose Urea Cycle STAT Family Protein Binding NSL Complex Urea Metabolic Process HMG Box Domain Binding Response To Nutrient Levels Nitrogen Cycle Metabolic Process Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Inflammatory Response White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process
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