TXNDC2

Description		thioredoxin domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding
	Biological Process	Spermatogenesis Cell Differentiation Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways
Drugs
Diseases
GWAS		Hip circumference ( 28552196) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)
Novel Interacting Genes		1 novel interacting genes: DDIT3
Interacting Genes		1 interacting genes: DDIT3
Entrez ID		84203
HPRD ID		11654
Ensembl ID		ENSG00000168454
Uniprot IDs		A0A140VJY8 Q86VQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Determination Of Dorsal Identity Involuntary Skeletal Muscle Contraction CHOP-C/EBP Complex CHOP-ATF4 Complex CHOP-ATF3 Complex Diaphragm Contraction Cellular Response To Nitrosative Stress Vascular Associated Smooth Muscle Cell Migration Transcription Regulator Activator Activity ATF6-mediated Unfolded Protein Response GDF15-GFRAL Signaling Pathway PERK-mediated Unfolded Protein Response HRI-mediated Signaling ER Overload Response Blood Vessel Maturation Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Interleukin-4 Production CAMP Response Element Binding Protein Binding Response To Nitrosative Stress Smooth Muscle Cell Proliferation Response To Caloric Restriction Vascular Associated Smooth Muscle Cell Proliferation Leucine Zipper Domain Binding Smooth Muscle Cell Migration Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Response To Platelet-derived Growth Factor Muscle Cell Migration Negative Regulation Of Myoblast Differentiation Respiratory System Process Cell Redox Homeostasis Anterior/posterior Axis Specification Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Skeletal Muscle Contraction Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Interleukin-4 Production Transcription Regulator Inhibitor Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Type II Interferon Production ER-nucleus Signaling Pathway Integrated Stress Response Signaling Calcium Ion Import Protein-DNA Complex Muscle Cell Proliferation Artery Development Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion
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