ZNRF3

Description		zinc and ring finger 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Limb Development Regulation Of Canonical Wnt Signaling Pathway Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		A body shape index ( 34021172) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Diastolic blood pressure ( 30487518 27618448) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448 30487518 29403010) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 25086665 29422604) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418 27618448) Type 2 diabetes ( 32499647) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: C3orf52 EPOR GFI1B HOXA1 HSPB1 RNF43 RSPO1 RSPO3 UBE2N
Entrez ID		84133
HPRD ID		11737
Ensembl ID		ENSG00000183579
Uniprot IDs		Q9ULT6
PDB IDs		8G4Y 8XFP 8XFS 8XFT 8Y69
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Erythropoietin Receptor Activity Semicircular Canal Formation Negative Regulation Of Protein Kinase C Signaling Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Frizzled Binding Abducens Nerve Formation Optokinetic Behavior Wnt Receptor Catabolic Process Ubiquitin Binding Positive Regulation Of Canonical Wnt Signaling Pathway Protein Kinase C Inhibitor Activity UBC13-MMS2 Complex
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