HDAC10

Description		histone deacetylase 10
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Histone Deacetylase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Deacetylase Activity Enzyme Binding Protein Lysine Deacetylase Activity Histone Deacetylase Binding Metal Ion Binding Acetylputrescine Deacetylase Activity Acetylspermidine Deacetylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Recombination Chromatin Organization Regulation Of DNA-templated Transcription Autophagy DNA Damage Response Macroautophagy Positive Regulation Of Mismatch Repair Homologous Recombination Negative Regulation Of DNA-templated Transcription Macromolecule Deacylation Polyamine Deacetylation Spermidine Deacetylation
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway
Drugs		Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac
Diseases
GWAS		Acne (severe) ( 24927181) Urinary metabolite levels in chronic kidney disease ( 31959995)
Novel Interacting Genes		9 novel interacting genes: HDAC2 HDAC3 HSPA8 MDC1 MTNR1A NCOR2 PAX3 TRIM28 TRIM54
Interacting Genes		9 interacting genes: HDAC2 HDAC3 HSPA8 MDC1 MTNR1A NCOR2 PAX3 TRIM28 TRIM54
Entrez ID		83933
HPRD ID		09407
Ensembl ID		ENSG00000100429
Uniprot IDs		Q969S8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein De-2-hydroxyisobutyrylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Rhythmic Process Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Histone Deacetylase Binding Heterochromatin Formation Circadian Rhythm Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin NF-kappaB Binding Transcription Corepressor Activity Positive Regulation Of Protein Import Into Nucleus Histone Deacetylase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Male Mating Behavior Heat Shock Protein Binding Response To Lipid Chaperone-mediated Autophagy Translocation Complex Disassembly Transcription Repressor Complex Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Ferroptosis Cellular Response To Stress Chromatin Organization Promoter-specific Chromatin Binding Nucleoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Enzyme Binding Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Transcription By RNA Polymerase II Lumenal Side Of Lysosomal Membrane Krueppel-associated Box Domain Binding Positive Regulation Of Protein Localization To Nucleus Regulation Of Protein Transport Regulation Of Interleukin-1 Production Fungiform Papilla Formation Regulation Of Protein Import Ubiquitin-like Protein Ligase Activity
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