PARP9

Description		poly(ADP-ribose) polymerase family member 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Protein-containing Complex Site Of DNA Damage
	Molecular Function	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Enzyme Inhibitor Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding NAD+ Binding ADP-D-ribose Binding STAT Family Protein Binding NAD+-protein-C-terminal Glycine ADP-ribosyltransferase Activity
	Biological Process	DNA Damage Checkpoint Signaling Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process DNA Repair Double-strand Break Repair DNA Damage Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Viral Protein Processing NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Chromatin Binding Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of DNA-templated Transcription Defense Response To Virus Regulation Of Response To Type II Interferon Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Type II Interferon-mediated Signaling Pathway Protein Poly-ADP-ribosylation Positive Regulation Of Protein Localization To Nucleus
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS		LDL cholesterol levels ( 32203549) Major depressive disorder ( 22472876) Parkinson's disease ( 32201043) Total cholesterol levels ( 30275531)
Novel Interacting Genes		3 novel interacting genes: ANXA1 DTX3L H2BC21
Interacting Genes		3 interacting genes: ANXA1 DTX3L H2BC21
Entrez ID		83666
HPRD ID		10686
Ensembl ID		ENSG00000138496
Uniprot IDs		Q59ER9 Q8IXQ6
PDB IDs		5AIL
Enriched GO Terms of Interacting Partners?		Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Immune Response Early Endosome Membrane Defense Response Response To External Biotic Stimulus Response To Other Organism Histone Ubiquitin Ligase Activity Histone H4K91 Ubiquitin Ligase Activity Myoblast Migration Involved In Skeletal Muscle Regeneration Positive Regulation Of Neutrophil Apoptotic Process Protein ADP-ribosyltransferase-substrate Adaptor Activity Regulation Of Neutrophil Apoptotic Process Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Early Endosome Neutrophil Clearance Phospholipase A2 Inhibitor Activity Positive Regulation Of Chromatin Binding Immune System Process Phospholipase Inhibitor Activity Regulation Of T-helper 1 Cell Differentiation Neutrophil Homeostasis Regulation Of Cell Cycle Phase Transition Positive Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Protein Localization To Early Endosome STAT Family Protein Binding Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Localization To Endosome Myoblast Migration Negative Regulation Of Type 2 Immune Response Peptide Cross-linking Cadherin Binding Involved In Cell-cell Adhesion Negative Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of T-helper Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Phagocytic Cup Positive Regulation Of Leukocyte Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Monocyte Chemotaxis Negative Regulation Of T-helper Cell Differentiation Apoptotic Cell Clearance Regulation Of Cell Cycle Process Arachidonate Secretion Negative Regulation Of Interleukin-8 Production Positive Regulation Of Vesicle Fusion
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