TCF7L1

Description		transcription factor 7 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Specification of the neural plate border Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Platelet distribution width ( 32888494) Pulse pressure ( 27841878 28135244 30487518 30578418) Total body bone mineral density ( 29304378)
Novel Interacting Genes		1 novel interacting genes: CTNNB1
Interacting Genes		1 interacting genes: CTNNB1
Entrez ID		83439
HPRD ID		06874
Ensembl ID		ENSG00000152284
Uniprot IDs		Q9HCS4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Catenin-TCF7L2 Complex Regulation Of Timing Of Anagen Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Central Nervous System Vasculogenesis Cranial Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Hair Follicle Placode Formation Dorsal Root Ganglion Development Establishment Of Blood-retinal Barrier Response To Indole-3-methanol Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Blood Vessel Branching Endodermal Cell Fate Commitment Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Limb Joint Morphogenesis Detection Of Muscle Stretch Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Odontoblast Differentiation
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