FZD6

Description		frizzled class receptor 6
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cilium Cell Surface Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body Apical Part Of Cell
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Platelet Activation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Embryonic Nail Plate Morphogenesis Inner Ear Morphogenesis Establishment Of Body Hair Planar Orientation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Midbrain Morphogenesis
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883)
Novel Interacting Genes		3 novel interacting genes: CCDC88C SFRP1 WNT4
Interacting Genes		3 interacting genes: CCDC88C SFRP1 WNT4
Entrez ID		8323
HPRD ID		04559
Ensembl ID		ENSG00000164930
Uniprot IDs		B4DL33 B4E236 O60353
PDB IDs		8JH7 8JHB
Enriched GO Terms of Interacting Partners?		Frizzled Binding Non-canonical Wnt Signaling Pathway Wnt Signaling Pathway Female Gonad Development Positive Regulation Of Focal Adhesion Assembly Regulation Of Supramolecular Fiber Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Morphogenesis Of An Epithelium Kidney Epithelium Development Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cell-substrate Junction Organization Regulation Of Animal Organ Morphogenesis Regulation Of Stress Fiber Assembly Canonical Wnt Signaling Pathway Stem Cell Differentiation Positive Regulation Of Cell Junction Assembly Regulation Of Ossification Male Gonad Development Tube Formation Negative Regulation Of Cellular Response To Growth Factor Stimulus Convergent Extension Involved In Somitogenesis Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Gonad Development Regulation Of Osteoblast Differentiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Cell Fate Commitment Positive Regulation Of Supramolecular Fiber Organization Regulation Of Reproductive Process Regulation Of Organelle Organization Cellular Response To Starvation Nephron Morphogenesis Positive Regulation Of Glucocorticoid Biosynthetic Process
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