QTRT1

Description		queuine tRNA-ribosyltransferase catalytic subunit 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Protein-containing Complex TRNA-guanine Transglycosylase Complex Transferase Complex
	Molecular Function	Protein Binding TRNA-guanosine(34) Queuine Transglycosylase Activity Transferase Activity Glycosyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	TRNA Wobble Guanine Modification TRNA Modification TRNA Processing
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FVC) ( 30804560) Psoriasis ( 25903422)
Novel Interacting Genes		8 novel interacting genes: COPS6 COXFA4L2 LCOR RHOU SETDB1 SH3GL3 UNC119 ZBTB16
Interacting Genes		8 interacting genes: COPS6 COXFA4L2 LCOR RHOU SETDB1 SH3GL3 UNC119 ZBTB16
Entrez ID		81890
HPRD ID		17943
Ensembl ID		ENSG00000213339
Uniprot IDs		Q71RF8 Q9BXR0
PDB IDs		6H42 6H45 7NQ4 8OMR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Transcription Corepressor Binding Negative Regulation Of Endocytosis Endocytosis Type 2 Angiotensin Receptor Binding Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Receptor-mediated Endocytosis Male Germ-line Stem Cell Asymmetric Division Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Histone H3K9 Trimethyltransferase Activity Central Nervous System Development
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