TMPRSS5

Description		transmembrane serine protease 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuronal Cell Body
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Chronic lymphocytic leukemia ( 28165464) Chronotype ( 30696823) Feeling guilty ( 29500382) Height ( 28552196) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Neurological blood protein biomarker levels ( 31320639) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346) Worry too long after an embarrassing experience ( 29500382)
Novel Interacting Genes		1 novel interacting genes: FBXO7
Interacting Genes		1 interacting genes: FBXO7
Entrez ID		80975
HPRD ID		05995
Ensembl ID		ENSG00000166682
Uniprot IDs		B7Z247 F5GX83 F5GYA3 F5H0U3 F5H2M3 Q0P513 Q0P514 Q9H3S3
PDB IDs
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitophagy Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Autophagy Of Mitochondrion Autophagy Of Mitochondrion SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex Positive Regulation Of Macroautophagy Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Ubiquitin Binding Negative Regulation Of Hemopoiesis Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Autophagy Negative Regulation Of Neuron Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Activation Protein Targeting Regulation Of Lymphocyte Differentiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Macroautophagy Negative Regulation Of Leukocyte Activation Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Lymphocyte Differentiation Ubiquitin-protein Transferase Activity
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