MPIG6B

Description		megakaryocyte and platelet inhibitory receptor G6b
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Heparin Binding
	Biological Process	Integrin-mediated Signaling Pathway Blood Coagulation Negative Regulation Of Signal Transduction Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Megakaryocyte Development
Pathways		GPVI-mediated activation cascade
Drugs
Diseases
GWAS		Hypertension ( 31879980)
Novel Interacting Genes		2 novel interacting genes: PTPN11 PTPN6
Interacting Genes		2 interacting genes: PTPN11 PTPN6
Entrez ID		80739
HPRD ID		09405
Ensembl ID		ENSG00000204420
Uniprot IDs		B0V023 O95866
PDB IDs		6R0X
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Type I Interferon-mediated Signaling Pathway Phosphotyrosine Residue Binding T Cell Costimulation Regulation Of Cell Adhesion Mediated By Integrin Myeloid Cell Development Negative Regulation Of T Cell Proliferation Protein Dephosphorylation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Adhesion Molecule Binding Protein Tyrosine Phosphatase Activity Negative Regulation Of Leukocyte Proliferation Dephosphorylation Myeloid Leukocyte Activation Phosphoprotein Phosphatase Activity Negative Regulation Of T Cell Activation Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Activation Regulation Of Tumor Necrosis Factor Production Hemopoiesis Regulation Of Cytokine-mediated Signaling Pathway Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Activation Regulation Of Mononuclear Cell Proliferation Myeloid Cell Differentiation Positive Regulation Of T Cell Activation Intestinal Epithelial Cell Migration Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Cerebellar Cortex Formation
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