TET1

Description		tet methylcytosine dioxygenase 1
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GO Annotations	Cellular Component	Nucleus Chromosome Sin3-type Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Iron Ion Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Metal Ion Binding Dioxygenase Activity DNA 5-methylcytosine Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inner Cell Mass Cell Differentiation Chromatin Organization Chromatin Remodeling Protein O-linked Glycosylation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Stem Cell Population Maintenance Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species Epigenetic Regulation Of Gene Expression Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance
Pathways		TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Childhood body mass index ( 33045005) Chronotype ( 30696823) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Pulse pressure ( 30224653) Triglycerides ( 30275531)
Novel Interacting Genes		2 novel interacting genes: DDX21 MBD3
Interacting Genes		2 interacting genes: DDX21 MBD3
Entrez ID		80312
HPRD ID		09694
Ensembl ID		ENSG00000138336
Uniprot IDs		Q8NFU7
PDB IDs		6ASD
Enriched GO Terms of Interacting Partners?		B-WICH Complex RNA Polymerase Inhibitor Activity 7SK SnRNA Binding Negative Regulation Of Transcription By RNA Polymerase I Chromatin Remodeling Chromosome R-loop Processing Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Positive Regulation Of Dendritic Cell Cytokine Production Ventricular Cardiac Muscle Tissue Development Response To Bisphenol A Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Dendritic Cell Cytokine Production NuRD Complex SnoRNA Binding Chromatin Organization Regulation Of Cell Fate Specification Regulation Of Transcription By RNA Polymerase III Methyl-CpG Binding Positive Regulation Of Transcription By RNA Polymerase I MiRNA Binding Response To Exogenous DsRNA Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Nucleosomal DNA Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Response To DsRNA Regulation Of Transcription By RNA Polymerase I Negative Regulation Of RNA Biosynthetic Process RRNA Binding Regulation Of Cell Fate Commitment Heterochromatin Negative Regulation Of RNA Metabolic Process Constitutive Heterochromatin Formation Cardiac Muscle Tissue Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-stranded RNA Binding RNA Helicase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of RNA Metabolic Process
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