CTC1

Description		CST telomere replication complex component 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytosol CST Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Telomere Maintenance DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Bone Marrow Development Chromosome Organization Hematopoietic Stem Cell Proliferation Replicative Senescence
Pathways		Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Telomere length ( 23001564)
Novel Interacting Genes		2 novel interacting genes: APPBP2 TPP1
Interacting Genes		2 interacting genes: APPBP2 TPP1
Entrez ID		80169
HPRD ID		07980
Ensembl ID		ENSG00000178971
Uniprot IDs		A0A8V8TP86 A0A8V8TQB6 J3KSZ1 Q2NKJ3
PDB IDs		5W2L 6W6W 7U5C 8D0B 8D0K 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process Sulfatide Binding Peptide Catabolic Process Protein Catabolic Process Lysophosphatidic Acid Binding Tripeptidyl-peptidase Activity Protein Catabolic Process In The Vacuole Cul2-RING Ubiquitin Ligase Complex Bone Resorption Macromolecule Catabolic Process Peptide Binding Microtubule Associated Complex Proteolysis Neuromuscular Process Controlling Balance Lysosome Organization Peptide Metabolic Process Microtubule Motor Activity Protein Localization To Chromosome Intracellular Protein Localization Melanosome Neuromuscular Process Catabolic Process Endopeptidase Activity Lysosomal Lumen Ubiquitin-like Ligase-substrate Adaptor Activity Serine-type Peptidase Activity
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