TUBA4B

Description		tubulin alpha 4b
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Cytoskeleton Organization Microtubule-based Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		CYT997
Diseases
GWAS		Platelet distribution width ( 27863252) Serum folate levels ( 29953918)
Novel Interacting Genes		2 novel interacting genes: CHPF GRIN1
Interacting Genes		2 interacting genes: CHPF GRIN1
Entrez ID		80086
HPRD ID		18242
Ensembl ID		ENSG00000243910
Uniprot IDs		Q9H853
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Glycine Glycine-gated Cation Channel Activity Propylene Metabolic Process N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity NMDA Glutamate Receptor Activity Glutamate Binding Acetylgalactosaminyltransferase Activity Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity NMDA Selective Glutamate Receptor Complex Glycine Binding Excitatory Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Neurotransmitter Receptor Complex Ligand-gated Sodium Channel Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Protein Heterotetramerization Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Regulation Of Calcium Ion Transport Into Cytosol Synaptic Cleft Chondroitin Sulfate Proteoglycan Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Protein Heterooligomerization Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Ligand-gated Ion Channel Signaling Pathway Terminal Bouton Regulation Of Reactive Oxygen Species Biosynthetic Process Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Visual Behavior Visual Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Reactive Oxygen Species Metabolic Process Excitatory Postsynaptic Potential Synaptic Membrane Response To Amyloid-beta Positive Regulation Of Calcium Ion Transmembrane Transport Golgi Cisterna Membrane Proteoglycan Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic Amyloid-beta Binding Calcium Channel Activity Proteoglycan Metabolic Process Calcium Ion Transmembrane Import Into Cytosol Protein Tetramerization Associative Learning
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