PSCA

Description		prostate stem cell antigen
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Synapse Extracellular Exosome Side Of Membrane
	Molecular Function	Acetylcholine Receptor Regulator Activity Acetylcholine Receptor Binding
	Biological Process	Negative Regulation Of ERK1 And ERK2 Cascade Acetylcholine Receptor Signaling Pathway Regulation Of Neurotransmitter Receptor Activity
Pathways		Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Bladder cancer ( 20972438 24163127 19648920 32117775) Blood urea nitrogen levels ( 31152163) Duodenal ulcer ( 22387998) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric atrophy ( 30753327) Gastric cancer ( 26098866 30189721) Non-cardia gastric cancer ( 26701879) Optic disc size ( 31809533) Pepsinogen I/II ratio ( 30753327) Schizophrenia ( 33169155) Severe gastric atrophy ( 30753327) Urinary tract infection frequency ( 28928442) Vertical cup-disc ratio ( 28073927)
Novel Interacting Genes		43 novel interacting genes: AGPAT5 AIG1 APOA2 APOL2 BCL2L2 BRICD5 CATSPERH CD53 CDIPT CMTM5 CTSA CYB561D2 DERL3 ERG28 INSIG2 JAGN1 LAT MOSPD3 PLP2 PLPP4 RUSF1 SLC16A4 SLC30A8 SLC35A1 SLC7A1 SMIM3 ST6GAL2 STX8 SYS1 TMEM140 TMEM147 TMEM218 TMEM239 TMEM243 TMEM42 TMEM54 TMEM86B TMEM97 TRARG1 TSPO2 UNC93A VAMP4 YIPF6
Interacting Genes		43 interacting genes: AGPAT5 AIG1 APOA2 APOL2 BCL2L2 BRICD5 CATSPERH CD53 CDIPT CMTM5 CTSA CYB561D2 DERL3 ERG28 INSIG2 JAGN1 LAT MOSPD3 PLP2 PLPP4 RUSF1 SLC16A4 SLC30A8 SLC35A1 SLC7A1 SMIM3 ST6GAL2 STX8 SYS1 TMEM140 TMEM147 TMEM218 TMEM239 TMEM243 TMEM42 TMEM54 TMEM86B TMEM97 TRARG1 TSPO2 UNC93A VAMP4 YIPF6
Entrez ID		8000
HPRD ID		03919
Ensembl ID		ENSG00000167653
Uniprot IDs		O43653
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Sterol Metabolic Process Cholesterol Binding High-density Lipoprotein Particle Binding Establishment Of Protein Localization To Plasma Membrane CDP-diacylglycerol Metabolic Process Endosome To Plasma Membrane Protein Transport Endomembrane System Oxysterol Binding Lipid Metabolic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Glycerolipid Metabolic Process Cellular Localization Protein Localization To Membrane Trans-Golgi Network Insulin Metabolic Process
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