DENND1C

Description		DENN domain containing 1C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Endocytosis Endocytic Recycling
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) ( 23648065) Monocyte count ( 32888494)
Novel Interacting Genes		3 novel interacting genes: APP DAPK1 SNAPIN
Interacting Genes		3 interacting genes: APP DAPK1 SNAPIN
Entrez ID		79958
HPRD ID		13304
Ensembl ID		ENSG00000205744
Uniprot IDs		Q8IV53
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Axo-dendritic Transport Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Positive Regulation Of Late Endosome To Lysosome Transport Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cytoskeleton-dependent Intracellular Transport Developmental Maturation Microtubule-based Transport Transport Along Microtubule Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of NMDA Receptor Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Transport Terminal Button Organization Regulation Of Spontaneous Synaptic Transmission Chemical Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Trans-synaptic Signaling Axon Choice Point Recognition Synaptic Signaling Heparan Sulfate Binding Signaling Receptor Activator Activity Synaptic Vesicle Maturation Regulation Of Lysosome Size
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