ATAD5

Description		ATPase family AAA domain containing 5
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GO Annotations	Cellular Component	Nucleus Elg1 RFC-like Complex
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity DNA Clamp Unloader Activity
	Biological Process	DNA Damage Response Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of B Cell Proliferation Nuclear DNA Replication Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Isotype Switching Positive Regulation Of DNA Replication Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways
Drugs
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body mass index ( 28892062) Breast cancer ( 25751625 29059683) Diastolic blood pressure ( 30224653) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 23563607 18391951) Hip circumference adjusted for BMI ( 25673412 34021172) Lung cancer in ever smokers ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500 34021172)
Novel Interacting Genes		2 novel interacting genes: PCNA RAD9A
Interacting Genes		2 interacting genes: PCNA RAD9A
Entrez ID		79915
HPRD ID		07792
Ensembl ID		ENSG00000176208
Uniprot IDs		Q96QE3
PDB IDs		8UI7 8UI8 8UI9 8UII
Enriched GO Terms of Interacting Partners?		PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Cellular Response To Radiation Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Enzyme Binding Checkpoint Clamp Complex Response To Radiation Double-stranded DNA 3'-5' DNA Exonuclease Activity DNA Repair MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Regulation Of Cellular Response To Stress Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Estrous Cycle Nuclear Lamina DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling DNA Strand Elongation Nuclear Replication Fork Response To L-glutamate DNA Metabolic Process DNA Damage Response Ovulation Cycle DNA Replication Checkpoint Signaling 3'-5' Exonuclease Activity Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Polymerase Binding Translesion Synthesis Histone Acetyltransferase Binding Replication Fork Liver Regeneration Mismatch Repair Postreplication Repair Replication Fork Processing Nuclear Estrogen Receptor Binding DNA Synthesis Involved In DNA Repair Response To Cadmium Ion Positive Regulation Of DNA Replication Response To Dexamethasone Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of DNA Biosynthetic Process Exonuclease Activity Male Germ Cell Nucleus
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