STEAP4

Description		STEAP4 metalloreductase
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Extracellular Exosome
	Molecular Function	Cupric Reductase (NADH) Activity Electron Transfer Activity Oxidoreductase Activity Heme Binding Metal Ion Binding Ferric-chelate Reductase (NADPH) Activity FAD Binding
	Biological Process	Monoatomic Ion Transport Iron Ion Transport Copper Ion Import Iron Import Into Cell Fat Cell Differentiation Protein Homotrimerization
Pathways		Transferrin endocytosis and recycling
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)
Novel Interacting Genes		2 novel interacting genes: AKT2 TERT
Interacting Genes		2 interacting genes: AKT2 TERT
Entrez ID		79689
HPRD ID		11637
Ensembl ID		ENSG00000127954
Uniprot IDs		Q687X5
PDB IDs		6HCY 6HD1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport Regulation Of D-glucose Import Regulation Of D-glucose Transmembrane Transport Cellular Response To High Light Intensity TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Response To High Light Intensity Retinal Rod Cell Apoptotic Process Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Positive Regulation Of Cap-dependent Translational Initiation RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity Regulation Of Protein Stability Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Cytoplasmic Translational Initiation Positive Regulation Of Protein Localization To Nucleolus Retinal Cell Apoptotic Process Telomerase Activity Establishment Of Protein Localization To Telomere Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance SiRNA Processing Positive Regulation Of Cell Migration Positive Regulation Of Fatty Acid Beta-oxidation Nuclear Telomere Cap Complex Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Protein Localization To Nucleolus Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fatty Acid Oxidation Telomere Maintenance Via Recombination Myelin Maintenance Response To Light Intensity Replicative Senescence Regulation Of PERK-mediated Unfolded Protein Response DNA Polymerase Activity Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Glycogen Biosynthetic Process Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process DNA Strand Elongation Mitotic Recombination Positive Regulation Of Transport
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