USB1

Description		U6 snRNA biogenesis phosphodiesterase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Intercellular Bridge
	Molecular Function	3'-5'-RNA Exonuclease Activity Nuclease Activity Protein Binding Hydrolase Activity Lyase Activity Poly(U)-specific Exoribonuclease Activity, Producing 3' Uridine Cyclic Phosphate Ends
	Biological Process	RNA Splicing SnRNA 3'-end Processing U6 SnRNA 3'-end Processing
Pathways
Drugs
Diseases		Poikiloderma with neutropenia
GWAS
Novel Interacting Genes		2 novel interacting genes: RNU6-1 SMAD4
Interacting Genes		2 interacting genes: RNU6-1 SMAD4
Entrez ID		79650
HPRD ID		07815
Ensembl ID		ENSG00000103005
Uniprot IDs		H3BN52 H3BNM8 Q9BQ65
PDB IDs		4H7W 5V1M 6D2Z 6D30 6D31
Enriched GO Terms of Interacting Partners?		Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Formation Of Quadruple SL/U4/U5/U6 SnRNP SMAD Protein Complex Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Brainstem Development Mesendoderm Development Sulfate Binding Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Endocardial Cell Differentiation U4 SnRNA Binding Atrioventricular Canal Development Somite Rostral/caudal Axis Specification Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Cardiac Muscle Cell Differentiation Endothelial Cell Activation U6 SnRNP Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Cardiocyte Differentiation Secondary Palate Development Filamin Binding Neural Crest Cell Differentiation Heart Valve Formation Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process I-SMAD Binding Cardiac Conduction System Development Interleukin-6-mediated Signaling Pathway Gastrulation With Mouth Forming Second Regulation Of Cell Proliferation Involved In Heart Morphogenesis Spliceosomal Tri-snRNP Complex Assembly Regulation Of Cardiac Muscle Cell Differentiation Seminiferous Tubule Development Regulation Of Hair Follicle Development Regulation Of Extracellular Matrix Assembly Uterus Development Female Gonad Development
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