METTL16

Description		methyltransferase 16, RNA N6-adenosine
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GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	MRNA M(6)A Methyltransferase Activity RNA Binding Methyltransferase Activity Transferase Activity U6 SnRNA 3'-end Binding RNA Stem-loop Binding U6 SnRNA (adenine-(43)-N(6))-methyltransferase Activity
	Biological Process	RNA Methylation MRNA Processing MRNA Catabolic Process S-adenosylmethionine Biosynthetic Process RNA Modification Post-transcriptional Regulation Of Gene Expression Methylation Regulation Of MRNA Stability Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RRNA Base Methylation SnRNA (adenine-N6)-methylation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization
Pathways
Drugs
Diseases
GWAS		Feeling miserable ( 29500382) Hip circumference adjusted for BMI ( 34021172) Red blood cell count ( 32888494)
Novel Interacting Genes		2 novel interacting genes: APP RNU6-1
Interacting Genes		2 interacting genes: APP RNU6-1
Entrez ID		79066
HPRD ID		14556
Ensembl ID		ENSG00000127804
Uniprot IDs		B7Z3X7 Q86W50
PDB IDs		2H00 6B91 6B92 6DU4 6DU5 6GFK 6GFN 6GT5 6M1U
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Formation Of Quadruple SL/U4/U5/U6 SnRNP Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition U4 SnRNA Binding Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion U6 SnRNP Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle
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