NUP37

Description		nucleoporin 37
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytosol Nuclear Pore Outer Ring
	Molecular Function	Protein Binding
	Biological Process	Nucleocytoplasmic Transport Chromosome Segregation Protein Transport MRNA Transport Cell Division
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159) General risk tolerance (MTAG) ( 30643258) Height ( 19893584 25429064) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)
Novel Interacting Genes		5 novel interacting genes: LNX1 NUP160 NUP43 TGFBR1 UBC
Interacting Genes		5 interacting genes: LNX1 NUP160 NUP43 TGFBR1 UBC
Entrez ID		79023
HPRD ID		14853
Ensembl ID		ENSG00000075188
Uniprot IDs		B4DKV8 Q8NFH4
PDB IDs		5A9Q 7PEQ 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Nuclear Pore Outer Ring Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex RNA Transport MRNA Transport Kinetochore Nuclear Pore Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Ventricular Compact Myocardium Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Germ Cell Migration Transforming Growth Factor Beta Receptor Activity Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Activity, Type I Nuclear Transport Nucleocytoplasmic Transport Nucleobase-containing Compound Transport Nuclear Envelope Coronary Artery Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Type II Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Ubiquitin Protein Ligase Binding Coronary Vasculature Morphogenesis Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Nephron Development Ventricular Trabecula Myocardium Morphogenesis Protein Tag Activity I-SMAD Binding Synapse Maturation Pharyngeal System Development Serine/threonine Protein Kinase Complex Heart Trabecula Morphogenesis Transforming Growth Factor Beta Binding Regulation Of Extracellular Matrix Assembly Structural Constituent Of Nuclear Pore Filopodium Assembly
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