XDH

Description		xanthine dehydrogenase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Cytosol Sarcoplasmic Reticulum
	Molecular Function	Xanthine Dehydrogenase Activity Xanthine Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Molybdopterin Cofactor Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding Hypoxanthine Dehydrogenase Activity Hypoxanthine Oxidase Activity FAD Binding
	Biological Process	Allantoin Metabolic Process Guanine Catabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Deoxyguanosine Catabolic Process AMP Catabolic Process IMP Catabolic Process Lactation Hypoxanthine Catabolic Process Xanthine Catabolic Process Iron-sulfur Cluster Assembly Regulation Of Epithelial Cell Differentiation Amide Catabolic Process GMP Catabolic Process DGMP Catabolic Process DAMP Catabolic Process
Pathways		Purine catabolism Butyrophilin (BTN) family interactions Azathioprine ADME
Drugs		Allopurinol Levocarnitine Topiroxostat Flavin adenine dinucleotide Dioxo(sulfanyl)molybdenum Eniluracil Niraxostat Febuxostat Oxypurinol
Diseases		Xanthinuria
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072) Multiple system atrophy ( 27629089) Obesity-related traits ( 23251661) Parahippocampal gyrus volume ( 31530798) Periventricular white matter hyperintensities ( 32517579) Zinc levels ( 26025379)
Novel Interacting Genes		2 novel interacting genes: BTN1A1 GRIP1
Interacting Genes		2 interacting genes: BTN1A1 GRIP1
Entrez ID		7498
HPRD ID		06363
Ensembl ID		ENSG00000158125
Uniprot IDs		P47989
PDB IDs		2CKJ 2E1Q
Enriched GO Terms of Interacting Partners?		Endosome To Plasma Membrane Protein Transport Establishment Of Protein Localization To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Regulation Of Neuron Projection Arborization Neurotransmitter Receptor Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Protein Localization To Postsynapse Signaling Receptor Complex Adaptor Activity Protein Localization To Postsynaptic Membrane Receptor Localization To Synapse Establishment Of Protein Localization To Plasma Membrane Protein Localization To Synapse Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
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