WNT2B

Description		Wnt family member 2B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding
	Biological Process	Chondrocyte Differentiation Lens Development In Camera-type Eye Male Gonad Development Cellular Response To Starvation Wnt Signaling Pathway Forebrain Regionalization Neuron Differentiation Cell Fate Commitment Animal Organ Development System Development Canonical Wnt Signaling Pathway Lung Induction Mesenchymal-epithelial Cell Signaling Iris Morphogenesis Cornea Development In Camera-type Eye Hematopoietic Stem Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518 29403010) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 28869591 30598549) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pancreatic cancer ( 29422604 26098869) Potassium levels ( 29403010) Pulse pressure ( 30487518) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418 30487518 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172)
Novel Interacting Genes		2 novel interacting genes: BRCA1 RAD21
Interacting Genes		2 interacting genes: BRCA1 RAD21
Entrez ID		7482
HPRD ID		03574
Ensembl ID		ENSG00000134245
Uniprot IDs		Q5TEH8 Q93097
PDB IDs
Enriched GO Terms of Interacting Partners?		Condensed Nuclear Chromosome Homologous Recombination Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Recombinational Repair Chromosome Segregation Regulation Of Cell Cycle G2/M Phase Transition Double-strand Break Repair Via Homologous Recombination Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex DNA Recombination Negative Regulation Of Cell Cycle Process Establishment Of Meiotic Sister Chromatid Cohesion Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle BRCA1-B Complex Negative Regulation Of Centriole Replication Positive Regulation Of Cytokine Production BRCA1-A Complex Regulation Of Mitotic Cell Cycle Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Ubiquitin-modified Histone Reader Activity DNA Repair Response To Indole-3-methanol Regulation Of Cell Cycle Phase Transition Cohesin Complex Establishment Of Sister Chromatid Cohesion Meiotic Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Cohesin Complex Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Sister Chromatid Cohesion Gamma-tubulin Ring Complex Negative Regulation Of Centrosome Duplication Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Chromosome DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome Negative Regulation Of Cellular Component Organization
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