LAT2

Description		linker for activation of T cells family member 2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding SH2 Domain Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway Calcium-mediated Signaling Intracellular Signal Transduction B Cell Activation Mast Cell Degranulation B Cell Receptor Signaling Pathway
Pathways		Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 29848360)
Novel Interacting Genes		8 novel interacting genes: CBL EIF4H GAB1 GRB2 PLCG1 PLCG2 SOS1 UBQLN4
Interacting Genes		8 interacting genes: CBL EIF4H GAB1 GRB2 PLCG1 PLCG2 SOS1 UBQLN4
Entrez ID		7462
HPRD ID		09304
Ensembl ID		ENSG00000086730
Uniprot IDs		Q9GZY6
PDB IDs		3MAZ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc-epsilon Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Kinase Binding Phosphotyrosine Residue Binding B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Immune Response-activating Signaling Pathway SH3 Domain Binding Phospholipase C Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Schwann Cell Development Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Ephrin Receptor Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cytosol Epidermal Growth Factor Receptor Binding COP9 Signalosome Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Response Protein Tyrosine Kinase Binding Phospholipid Catabolic Process Perinuclear Region Of Cytoplasm Positive Regulation Of Epithelial Cell Migration Phosphoric Diester Hydrolase Activity Positive Regulation Of Receptor-mediated Endocytosis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Intracellular Signaling Cassette Glial Cell Development Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Migration Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of ERBB Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response
Tagcloud ?