VRK1

Description		VRK serine/threonine kinase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Cytosol Cajal Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nucleosomal DNA Binding Histone H3S10 Kinase Activity Histone Binding Histone H3T3 Kinase Activity Protein Serine Kinase Activity Histone H2AX Kinase Activity
	Biological Process	Chromatin Remodeling Protein Phosphorylation DNA Damage Response Mitotic Nuclear Membrane Disassembly Signal Transduction Cajal Body Organization Neuron Projection Development Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Cell Division Golgi Disassembly Positive Regulation Of Protein Localization To Chromatin Regulation Of Neuron Migration
Pathways		Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation
Drugs
Diseases		Pontocerebellar hypoplasia
GWAS		Bone ultrasound measurement (velocity of sound) ( 28472463) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive function ( 24684796) Copper levels ( 26025379) Fractures (paediatric) ( 32742401) Metabolite levels ( 23823483) Neutrophil count ( 21507922) Night sleep phenotypes ( 27126917) Staphylococcus aureus infection ( 24847357)
Novel Interacting Genes		9 novel interacting genes: H2BC21 H3C14 HIF1A NBN OGT PLK3 SRPK2 TP53 VHL
Interacting Genes		9 interacting genes: H2BC21 H3C14 HIF1A NBN OGT PLK3 SRPK2 TP53 VHL
Entrez ID		7443
HPRD ID		03701
Ensembl ID		ENSG00000100749
Uniprot IDs		A0A7P0T838 A0A7P0TB08 H0YJF7 Q99986
PDB IDs		2KTY 2KUL 2LAV 2RSV 3OP5 5UKF 5UVF 6AC9 6BP0 6BRU 6BTW 6BU6 6CFM 6CMM 6CNX 6CQH 6CSW 6DD4 6NPN 6VXU 6VZH 7M10 7TAN 8F8Y 8V42
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleoplasm Neuroblast Proliferation Chromatin Organization Regulation Of Carbohydrate Catabolic Process P53 Binding Response To Stress Regulation Of Purine Nucleotide Metabolic Process Chromatin Remodeling R-loop Processing Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Precursor Cell Proliferation Signal Transduction By P53 Class Mediator Regulation Of Thymocyte Apoptotic Process Protein Heterodimerization Activity Negative Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Autophagy Mitotic G1/S Transition Checkpoint Signaling Lactate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Hypoxia Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction In Response To DNA Damage Regulation Of TOR Signaling Cellular Response To Oxygen Levels Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Intracellular Signal Transduction Replication Fork 14-3-3 Protein Binding Nucleus Negative Regulation Of Mitotic Cell Cycle Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Phase Transition Regulation Of T Cell Apoptotic Process Protein-containing Complex Assembly Regulation Of Neuroblast Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Chromosome Regulation Of Primary Metabolic Process
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