UROD

Description		uroporphyrinogen decarboxylase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Uroporphyrinogen Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity
	Biological Process	Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Porphyrin-containing Compound Catabolic Process Heme Metabolic Process Heme O Biosynthetic Process
Pathways		Heme biosynthesis
Drugs		Coproporphyrin I Coproporphyrinogen III
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS
Novel Interacting Genes		12 novel interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA PTPRF RUNX1 TSSK3 VIM
Interacting Genes		12 interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA PTPRF RUNX1 TSSK3 VIM
Entrez ID		7389
HPRD ID		01441
Ensembl ID		ENSG00000126088
Uniprot IDs		A0A494C0Q8 P06132
PDB IDs		1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Replication Multivesicular Body, Internal Vesicle Lumen Chondroitin Sulfate Proteoglycan Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Lymphocyte Differentiation
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