C5AR1

Description		complement C5a receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Secretory Granule Membrane Cytoplasmic Vesicle Apical Part Of Cell
	Molecular Function	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity
	Biological Process	Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Signaling Neutrophil Chemotaxis Response To Peptidoglycan Complement Component C5a Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Angiogenesis Astrocyte Activation Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Cognition Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Amyloid-beta Clearance Presynapse Organization
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Regulation of Complement cascade
Drugs		Avacopan
Diseases
GWAS		Chronic periodontitis ( 25008200)
Novel Interacting Genes		7 novel interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS
Interacting Genes		7 interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS
Entrez ID		728
HPRD ID		00224
Ensembl ID		ENSG00000197405
Uniprot IDs		P21730
PDB IDs		2K3U 5O9H 6C1Q 6C1R 7Y64 7Y65 7Y66 7Y67 8GO8 8GOO 8HK5 8I0N 8I0Z 8IA2 8JZP 8JZZ
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Angiotensin Receptor Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway Chemotaxis Locomotion Regulation Of Immune Response G Protein-coupled Receptor Internalization Regulation Of Interleukin-6 Production Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Immune System Process Negative Regulation Of Leukocyte Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Receptor Internalization Cell Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune System Process Regulation Of ERK1 And ERK2 Cascade Regulation Of Cytokine Production Postsynaptic Signal Transduction Negative Regulation Of Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Leukocyte Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Locomotion Endocytic Vesicle Membrane Receptor Internalization Positive Regulation Of Metabolic Process Regulation Of Receptor Internalization Clathrin-coated Pit Negative Regulation Of Protein Ubiquitination Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Motility Regulation Of T Cell Antigen Processing And Presentation Regulation Of Locomotion Regulation Of Interleukin-8 Production Negative Regulation Of Post-translational Protein Modification Positive Regulation Of MAPK Cascade Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Innate Immune Response Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Vesicle-mediated Transport
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