TPO

Description		thyroid peroxidase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane
	Molecular Function	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process	Thyroid Hormone Generation Response To Oxidative Stress Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification
Pathways		Thyroxine biosynthesis
Drugs		Carbimazole Dextrothyroxine Propylthiouracil Methimazole Triclosan Resorcinol 2-mercaptobenzothiazole
Diseases		Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Autoimmune thyroid disease ( 32581359) Hypothyroidism ( 27182965 30367059) Medication use (thyroid preparations) ( 31015401) Placebo response in major depressive disorder (% change in symptom score) ( 28696415) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183 24722205) Thyroid stimulating hormone levels ( 32769997)
Novel Interacting Genes		3 novel interacting genes: DUOX1 DUSP6 TXNDC11
Interacting Genes		3 interacting genes: DUOX1 DUSP6 TXNDC11
Entrez ID		7173
HPRD ID		06000
Ensembl ID		ENSG00000115705
Uniprot IDs		P07202 Q502Y3 Q6P534
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Nitrosative Stress MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Protein Tyrosine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Reactive Oxygen Species Biosynthetic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process NADPH Oxidase Complex NAD(P)H Oxidase H2O2-forming Activity Hydrogen Peroxide Catabolic Process Superoxide-generating NAD(P)H Oxidase Activity Hydrogen Peroxide Biosynthetic Process Cuticle Development Superoxide Anion Generation Peroxidase Activity Hydrogen Peroxide Metabolic Process NADP Binding Hormone Biosynthetic Process Superoxide Metabolic Process
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