TPMT

Description		thiopurine S-methyltransferase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Thiopurine S-methyltransferase Activity Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Xenobiotic Metabolic Process Methylation Xenobiotic Catabolic Process
Pathways		Methylation Defective TPMT causes TPMT deficiency Azathioprine ADME
Drugs		Olsalazine
Diseases		Thiopurine S-methyltransferase deficiency (TPMT deficiency)
GWAS		DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Erythrocyte thioguanine concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Thiopurine methyltransferase activity in acute lymphoblastic leukemia patients treated with mercaptopurines ( 27564568) Thiopurine S-methyltransferase activity ( 27770449) Thiopurine-induced myelosuppression in inflammatory bowel disease ( 30806694)
Novel Interacting Genes		3 novel interacting genes: APP DTNBP1 FGFR1
Interacting Genes		3 interacting genes: APP DTNBP1 FGFR1
Entrez ID		7172
HPRD ID		01760
Ensembl ID		ENSG00000137364
Uniprot IDs		P51580
PDB IDs		2BZG 2H11
Enriched GO Terms of Interacting Partners?		Regulation Of Postsynapse Organization Regulation Of Synapse Organization Positive Regulation Of Receptor Internalization Neuron Projection Development Positive Regulation Of Receptor-mediated Endocytosis Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Growth Cone Lamellipodium Positive Regulation Of Mitotic Cell Cycle Plasma Membrane Bounded Cell Projection Organization Axo-dendritic Transport Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Receptor-mediated Endocytosis Cytoplasmic Vesicle Memory Regulation Of Receptor Internalization Positive Regulation Of Transport Nervous System Process Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Synapse Assembly Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Cell Maturation Positive Regulation Of Endocytosis Growth Cone Positive Regulation Of Synaptic Transmission Cell Projection Organization Dendritic Spine Heparin Binding Positive Regulation Of Cellular Component Organization Acetylcholine Receptor Activator Activity Transport Along Microtubule Lipoprotein Particle Positive Regulation Of Protein Import Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Lateral Mesodermal Cell Fate Specification Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Neuron Differentiation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cytoskeleton-dependent Intracellular Transport Developmental Maturation Regulation Of Chemotaxis
Tagcloud ?