TPH1

Description		tryptophan hydroxylase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Neuron Projection
	Molecular Function	Monooxygenase Activity Tryptophan 5-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Metal Ion Binding
	Biological Process	Platelet Degranulation Serotonin Biosynthetic Process From Tryptophan Aromatic Amino Acid Metabolic Process Serotonin Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Bone Remodeling Mammary Gland Alveolus Development Regulation Of Hemostasis
Pathways		Serotonin and melatonin biosynthesis NGF-stimulated transcription
Drugs		Sapropterin LX1031 Telotristat ethyl
Diseases
GWAS		Glucose homeostasis traits ( 30576415) HDL cholesterol ( 30275531) White blood cell count ( 32888494)
Novel Interacting Genes		6 novel interacting genes: APP GORASP2 PRKACA PSTPIP1 YWHAH YWHAZ
Interacting Genes		6 interacting genes: APP GORASP2 PRKACA PSTPIP1 YWHAH YWHAZ
Entrez ID		7166
HPRD ID		01846
Ensembl ID		ENSG00000129167
Uniprot IDs		P17752
PDB IDs		1MLW 3HF6 3HF8 3HFB 5J6D 5L01 5TPG 7ZIF 7ZIG 7ZIH 7ZII 7ZIJ 7ZIK 8CJI 8CJJ 8CJK 8CJL 8CJM 8CJN 8CJO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Metal Ion Transport TOR Signaling Protein Domain Specific Binding Negative Regulation Of TORC1 Signaling TORC1 Signaling Glucocorticoid Catabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of Calcium-mediated Signaling Establishment Of Protein Localization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Establishment Of Localization In Cell Tube Formation Glutamatergic Synapse Transmembrane Transporter Binding Cerebellar Granule Cell To Purkinje Cell Synapse Synaptic Target Recognition Golgi Organization Regulation Of Calcium Ion Transmembrane Transport
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