TLL1

Description		tolloid like 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Proteolysis Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization
Pathways		Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index ( 28552196) Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176) Cerebrospinal fluid clusterin levels ( 26545630) Glomerular filtration rate in chronic kidney disease ( 26420894) Hepatocellular carcinoma in post hepatitis C eradication by interferon therapy ( 28163062) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29785010) Multiple sclerosis ( 23412934) Obesity-related traits ( 23251661) Post-traumatic stress disorder ( 23726511) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Serum bilirubin levels in metabolic syndrome ( 30621171) Type 1 diabetes (age at diagnosis) ( 33179336) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 34021172 28552196) Weight ( 28552196) Western dietary pattern ( 28644415)
Novel Interacting Genes		2 novel interacting genes: APP CHRD
Interacting Genes		2 interacting genes: APP CHRD
Entrez ID		7092
HPRD ID		07074
Ensembl ID		ENSG00000038295
Uniprot IDs		B7ZLW3 O43897
PDB IDs		3EDI
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Floor Plate Development Heparan Sulfate Binding Signaling Receptor Activator Activity Spinal Cord Dorsal/ventral Patterning Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle
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