TIMP4

Description		TIMP metallopeptidase inhibitor 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Secretory Granule Lumen
	Molecular Function	Enzyme Inhibitor Activity Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Notch Signaling Pathway Response To Hormone Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		4 novel interacting genes: CORO1C ERRFI1 MMP14 MMP2
Interacting Genes		4 interacting genes: CORO1C ERRFI1 MMP14 MMP2
Entrez ID		7079
HPRD ID		03557
Ensembl ID		ENSG00000157150
Uniprot IDs		Q99727
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Migration Macrophage Chemotaxis Chondrocyte Proliferation Negative Regulation Of Focal Adhesion Assembly Macrophage Migration Cell Motility Endodermal Cell Differentiation Negative Regulation Of Cell Adhesion Collagen Catabolic Process Negative Regulation Of Cell-matrix Adhesion Embryo Implantation Ovarian Follicle Development Extracellular Matrix Disassembly Sarcomere Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Estrogen Negative Regulation Of Cell-substrate Adhesion Collagen Metabolic Process Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Kinase Activity Animal Organ Morphogenesis Regulation Of Cell-substrate Junction Organization Negative Regulation Of Kinase Activity Tissue Remodeling Endopeptidase Activity Metalloendopeptidase Activity Response To Hormone Enzyme-linked Receptor Protein Signaling Pathway Mononuclear Cell Migration Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Negative Regulation Of Protein Phosphorylation Response To Estradiol Skeletal System Morphogenesis Negative Regulation Of Phosphorylation Regulation Of Cell-matrix Adhesion Ossification Myeloid Leukocyte Migration Metallopeptidase Activity Ameboidal-type Cell Migration Leukocyte Chemotaxis Regulation Of Cell Adhesion Serine-type Endopeptidase Activity Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Developmental Process Involved In Reproduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Epithelial Cell Proliferation
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