SULT1A1

Description		sulfotransferase family 1A member 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Aryl Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Flavonol 3-sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Ethanol Catabolic Process Catecholamine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Amine Metabolic Process Flavonoid Metabolic Process Thyroid Hormone Metabolic Process Dopamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		Cytosolic sulfonation of small molecules Paracetamol ADME
Drugs		Adenosine 3',5'-diphosphate P-Nitrophenol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Obesity (extreme) ( 30677029) Risk-taking tendency (4-domain principal component model) ( 30643258)
Novel Interacting Genes		2 novel interacting genes: SULT2B1 TYK2
Interacting Genes		2 interacting genes: SULT2B1 TYK2
Entrez ID		6817
HPRD ID		01372
Ensembl ID		ENSG00000196502
Uniprot IDs		P50225
PDB IDs		1LS6 1Z28 2D06 3QVU 3QVV 3U3J 3U3K 3U3M 3U3O 3U3R 4GRA
Enriched GO Terms of Interacting Partners?		Alcohol Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Cholesterol Sulfotransferase Activity Steroid Sulfotransferase Activity Steroid Hormone Binding Type II Interferon-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-12 Receptor Complex Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Interleukin-12-mediated Signaling Pathway Interleukin-23 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Sulfation Positive Regulation Of T-helper 17 Type Immune Response Small Molecule Binding Growth Hormone Receptor Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Sulfotransferase Activity Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Natural Killer Cell Activation Regulation Of T-helper 17 Type Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Receptor Signaling Pathway Via STAT Cholesterol Binding Phosphate-containing Compound Metabolic Process Type I Interferon-mediated Signaling Pathway Regulation Of Epidermal Cell Differentiation Regulation Of Epidermis Development Positive Regulation Of Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Type II Interferon Production Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Transferase Activity
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