STRN

Description		striatin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Postsynaptic Density Membrane Cell Junction Dendrite Cell Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane FAR/SIN/STRIPAK Complex Postsynapse
	Molecular Function	Protein Binding Calmodulin Binding Nuclear Estrogen Receptor Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding
	Biological Process	Locomotory Behavior Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Dendrite Development Bicellular Tight Junction Assembly
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Extra-nuclear estrogen signaling Signaling by cytosolic PDGFRA and PDGFRB fusion proteins ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alanine transaminase levels ( 29403010) Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 27863252) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) PR interval ( 32439900) QRS duration ( 27659466 27577874) Red cell distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549 32154731)
Novel Interacting Genes		12 novel interacting genes: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PDCD10 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11
Interacting Genes		12 interacting genes: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PDCD10 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11
Entrez ID		6801
HPRD ID		18124
Ensembl ID		ENSG00000115808
Uniprot IDs		O43815
PDB IDs
Enriched GO Terms of Interacting Partners?		FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Communication By Electrical Coupling Intracellular Signal Transduction INTAC Complex Regulation Of Cell Cycle Process RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Hippo Signaling Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Kinase Binding T Cell Homeostasis Nuclear RNA Surveillance Membrane Raft Fibroblast Proliferation RNA Surveillance Sister Chromatid Cohesion Protein Phosphatase Regulator Activity Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Muscle System Process Regulation Of Signaling Inward Rectifier Potassium Channel Inhibitor Activity Negative Regulation Of Endothelial Cell Proliferation RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity DNA-templated Transcription Elongation RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Regulation Of Action Potential Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Lymphocyte Homeostasis Regulation Of Nitric Oxide Metabolic Process Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Response To Metal Ion
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