SSTR4

Description		somatostatin receptor 4
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GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding Neuropeptide Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Somatostatin Signaling Pathway Cellular Response To Glucocorticoid Stimulus
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Somatostatin Lutetium Lu 177 dotatate
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood sugar levels ( 29403010) Hypothyroidism ( 27182965) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Vitamin D levels ( 26704534)
Novel Interacting Genes		2 novel interacting genes: CORT SST
Interacting Genes		2 interacting genes: CORT SST
Entrez ID		6754
HPRD ID		01676
Ensembl ID		ENSG00000132671
Uniprot IDs		P31391
PDB IDs		7XMS 7XMT
Enriched GO Terms of Interacting Partners?		Receptor Ligand Activity Hormone Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Somatostatin Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway Signaling Cell-cell Signaling Cell Communication G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Regulation Of Cell Motility Regulation Of Cell Migration Digestion Neuronal Dense Core Vesicle Response To Acidic PH Hyperosmotic Response Regulation Of Locomotion Response To PH Extracellular Space G Protein-coupled Receptor Binding Response To Osmotic Stress Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway GABA-ergic Synapse Response To Amino Acid Extracellular Region Response To Nutrient Hormone-mediated Signaling Pathway Response To Steroid Hormone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
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