SRP14

Description		signal recognition particle 14
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Secretory Granule Lumen Signal Recognition Particle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding 7S RNA Binding Endoplasmic Reticulum Signal Peptide Binding
	Biological Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Protein Targeting To ER
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Neutrophil degranulation
Drugs		Artenimol
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Ewing sarcoma ( 22327514) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Novel Interacting Genes		11 novel interacting genes: CALM1 CEBPA EAF1 FOXP1 IL7R NSFL1C PTEN SPANXN2 SRP9 TLE3 UBC
Interacting Genes		11 interacting genes: CALM1 CEBPA EAF1 FOXP1 IL7R NSFL1C PTEN SPANXN2 SRP9 TLE3 UBC
Entrez ID		6727
HPRD ID		02831
Ensembl ID		ENSG00000140319
Uniprot IDs		P37108
PDB IDs		1E8O 1E8S 1RY1 4UYJ 4UYK 5AOX 7NFX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Mononuclear Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Regulation Of Cell Size Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Leukocyte Apoptotic Process Interleukin-7 Receptor Activity Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Organ Growth Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Interleukin-21 Production VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Regulation Of Cell Development
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